Elucidating the mechanism of cellular uptake and bra datingsida

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Increasing use of silver nanoparticles (Ag-NPs) in various products is resulting in a greater likelihood of human exposure to these materials.Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles.Ag-NPs functionalized with three different monosaccharides and ethylene glycol were synthesized and characterised.Oxidative stress and toxicity was evaluated by protein carbonylation and MTT assay, respectively.

Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases.Here, to elucidate the effect of aspect ratio of rod-like nanoparticles on cellular uptake, tobacco mosaic virus (TMV), a typical rod-like bionanoparticle, is developed as a model.Nanorods with different aspect ratios can be obtained by ultrasound treatment and sucrose density gradient centrifugation.This work provides a fundamental understanding of the influence of aspect ratio on cellular uptake decoupled from charge and material composition.Cellular internalization pathway is essential to the understanding of viral infection and the development of therapeutic agents.

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